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152-58-9

  • Product Name:CORTEXOLONE
  • Molecular Formula:C21H30O4
  • Molecular Weight:346.467
  • Appearance:Crystalline solid
Inquiry

Product Details

pd_meltingpoint:205-208 °C

Appearance:Crystalline solid

Purity:99%

Factory sells CORTEXOLONE 152-58-9 with sufficient production capacity

  • Molecular Formula:C21H30O4
  • Molecular Weight:346.467
  • Appearance/Colour:Crystalline solid 
  • Melting Point:205-208 °C 
  • Refractive Index:120 ° (C=1, Dioxane) 
  • Boiling Point:524.518 °C at 760 mmHg 
  • PKA:12?+-.0.60(Predicted) 
  • Flash Point:285.097 °C 
  • PSA：74.60000 
  • Density:1.222 g/cm3 
  • LogP:2.81080 

152-58-9 Relevant articles

Danazol Inhibits Human Adrenal 21- and 11β-Hydroxylation in vitro

Barbieri, Robert L.,Osathanondh, Rapin,Canick, Jacob A.,Stillman, Robert J.,Ryan, Kenneth J.

, p. 251 - 263 (1980)

The effects of danazol on steroidogenesi...

Simple Route for Elaboration of the Hydroxy-ketone and Dihydroxy-acetone Side-chains of Corticosteroids from 17-Oxo-steroids

Nedelec, Lucien,Torelli, Vesperto,Hardy, Michel

, p. 775 - 777 (1981)

α-Formylaminoacrylic esters, produced by...

-

v.Euw,Reichstein

, p. 1140,1142 (1941)

-

An efficient hemisynthesis of 20- and 21-[13C]-labeled cortexolone: A model for the study of skin sensitization to corticosteroids

Claudel, Emilie,Arbez-Gindre, Cecile,Berl, Valerie,Lepoittevin, Jean-Pierre

, p. 3391 - 3398 (2009)

A method is described for the synthesis ...

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes

Gonzalez, Eric,Johnson, Kevin M.,Pallan, Pradeep S.,Phan, Thanh T.N.,Zhang, Wei,Lei, Li,Wawrzak, Zdzislaw,Yoshimoto, Francis K.,Egli, Martin,Peter Guengerich

, p. 541 - 556 (2018)

Cytochrome P450 (P450) 17A1 catalyzes th...

-

Reichstein

, p. 1490,1496 (1938)

-

-

Reichstein,v.Euw

, p. 1258 (1940)

-

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia

Wang, Chunxue,Pallan, Pradeep S.,Zhang, Wei,Lei, Li,Yoshimoto, Francis K.,Waterman, Michael R.,Egli, Martin,Guengerich, F. Peter

, p. 10767 - 10778 (2017)

Cytochrome P450 (P450, CYP) 21A2 is the ...

Conversion of progesterone to corticosteroids by the midterm fetal adrenal and kidney

McShane,deM. Fencl

, p. 299 - 310 (1983)

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BIOSYNTHESIS OF ANDROGENS BY PHEOCHROMOCYTOMAS

Carballeira, Andres,Brown, John W.,Fishman, Lawrence M.

, p. 647 - 660 (1989)

Homogenates from four adrenal pheochromo...

Human cytochrome P450 21A2, the major steroid 21-hydroxylase: Structure of the enzyme?progesterone substrate complex and rate-limiting C-H bond cleavage

Pallan, Pradeep S.,Wang, Chunxue,Lei, Li,Yoshimoto, Francis K.,Auchus, Richard J.,Waterman, Michael R.,Guengerich, F. Peter,Egli, Martin

, p. 13128 - 13143 (2015)

Cytochrome P450 (P450) 21A2 is the major...

P450BM3 on steroids: The Swiss Army Knife P450 enzyme just gets better

Wong, Luet-Lok

scheme or table, p. 2537 - 2539 (2012/05/07)

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152-58-9 Process route

Progesterone
57-83-0

Progesterone

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

Corticosterone
50-22-6

Corticosterone

Cortexolone
152-58-9

Cortexolone

Conditions
Conditions Yield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human kidney tissue; NADP; magnesium chloride; at 37 ℃; for 2h; Product distribution; <3H>labeled;
2.3 % Chromat.
21.1 % Chromat.
32.5 % Chromat.
Progesterone
57-83-0

Progesterone

HYDROCORTISONE
50-23-7

HYDROCORTISONE

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

Corticosterone
50-22-6

Corticosterone

Cortexolone
152-58-9

Cortexolone

Conditions
Conditions Yield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human adrenal tissue; NADP; magnesium chloride; at 37 ℃; for 2h; Product distribution; <3H>labeled;
4.7 % Chromat.
36.3 % Chromat.

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