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Purity:99%
The present invention relates to a proce...
Compounds of formula (a), (b), (c), or (...
ethyl bromide
(1R,2R,3S)-2-hydroxymethyl-3-(3,4-dichlorophenyl)-tropane
(1R,2R,3S)-2-ethoxymethyl-3-(3,4-dichlorophenyl)-tropane citrate
| Conditions | Yield |
|---|---|
|
ethyl bromide; (1R,2R,3S)-2-hydroxymethyl-3-(3,4-dichlorophenyl)-tropane;
With
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate;
In
1,2-dimethoxyethane;
at 20 - 62 ℃;
for 2.75h;
In
methanol; acetone;
at 15 - 55 ℃;
for 1h;
Product distribution / selectivity;
|
83.85% |
(1R,2R,3S)-2-hydroxymethyl-3-(3,4-dichlorophenyl)-tropane
citric acid
(1R,2R,3S)-2-ethoxymethyl-3-(3,4-dichlorophenyl)-tropane citrate
| Conditions | Yield |
|---|---|
|
ethyl bromide; (1R,2R,3S)-2-hydroxymethyl-3-(3,4-dichlorophenyl)-tropane;
With
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate;
In
1,2-dimethoxyethane;
at 20 - 62 ℃;
for 2.75h;
citric acid;
In
methanol; acetone;
at 15 - 40 ℃;
for 1h;
Product distribution / selectivity;
|
83.6% |
ethyl bromide
(1R,2R,3S)-2-hydroxymethyl-3-(3,4-dichlorophenyl)-tropane
citric acid
ethyl sulfate
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