What is the 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid?

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid is , while it's Molecular Formula is C 18 H 14 N 2 O 5 . 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

What is the CAS number for 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid?

The CAS number of 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid is 1572936-83-4.

What is 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid (1572936-83-4) used for?

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

What is the 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid?

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid is , while it's Molecular Formula is C 18 H 14 N 2 O 5 . 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

What is the CAS number for 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid?

The CAS number of 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid is 1572936-83-4.

What is 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid (1572936-83-4) used for?

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Product classification

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1572936-83-4

Product Name:MONNA
Molecular Weight:338.32

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Product Details

Purity:99%

Reputable factory supply MONNA 1572936-83-4 in stock with high standard

Molecular Formula:C₁₈H₁₄N₂O₅
Molecular Weight:338.32

1572936-83-4 Relevant articles

NOVEL COMPOUNDS AS CHLORIDE CHANNEL BLOCKING AGENT

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Paragraph 0178; 0179; 0180; 0181; 0182; 0183; 0268-0270, (2015/06/03)

Disclosed is a novel compound to functio...

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Oh, Soo-Jin,Hwang, Seok Jin,Jung, Jonghoon,Yu, Kuai,Kim, Jeongyeon,Choi, Jung Yoon,Hartzell, H. Criss,Roh, Eun Joo,Justin Lee

, p. 726 - 735 (2013/11/06)

Transmembrane protein with unknown funct...

1572936-83-4 Process route

: C₁₉H₁₆N₂O₅

: 1572936-83-4
2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Conditions

Conditions	Yield
With water; lithium hydroxide; In tetrahydrofuran; methanol; Reflux;	98%

: 1572936-83-4
2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Conditions

Conditions	Yield
With water; lithium hydroxide; In tetrahydrofuran; methanol; for 1h; Reflux;	98%

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