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J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
3-methoxy-benzaldehyde
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: sodium acetate / ethanol; water / 0.33 h / 100 °C
2: triethylamine / dichloromethane / 0 °C / Inert atmosphere
With
sodium acetate; triethylamine;
In
ethanol; dichloromethane; water;
|
1-(2,4-dimethylphenyl)-2-(3-methoxybenzylidene)hydrazine
trifluoroacetic anhydride
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
|
83% |
The CAS number of J 147 is 1146963-51-0.
More information of J 147 1146963-51-0 are:
|
CAS Number |
1146963-51-0 |
|
Density |
1.18±0.1 g/cm3(Predicted) |
|
Boiling Point |
412.8±55.0 °C(Predicted) |
|
PSA |
41.90000 |
|
LogP |
4.24140 |
|
Pka |
0.80±0.50(Predicted) |
Synonyms for J 147 1146963-51-0:J 147;J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
The chemical formula of J 147 is C18H17F3N2O2 which containing 18 Carbon atoms,17 Hydrogen atoms,3 Fluorine atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of J 147 is 350.3349896.
J 147 is a novel neurotrophic drug that serves as a cognitive enhancer and a therapeutic agent for Alzheimer's disease. It is an exceptionally potent, orally active, and broadly neuroprotective compound that has demonstrated the ability to enhance memory in normal animals and prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J 147 are linked to an increase in brain-derived neurotrophic factor (BDNF) levels, the expression of BDNF-responsive proteins, the enhancement of long-term potentiation (LTP), the preservation of synaptic proteins, and the reduction of amyloid plaques.
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