What is the HEMATOPORPHYRIN?

HEMATOPORPHYRIN is , while it's Molecular Formula is C34H38 N4 O6. Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

What is the CAS number for HEMATOPORPHYRIN?

The CAS number of HEMATOPORPHYRIN is 14459-29-1.

What is HEMATOPORPHYRIN (14459-29-1) used for?

HEMATOPORPHYRIN, also known as Photodyn or Sensibion, is a dicarboxylic acid that is a derivative of protoporphyrin IX. It is prepared from hemin and has its vinyl groups at positions 7 and 12 replaced by 1-hydroxyethyl groups. HEMATOPORPHYRIN is a porphyrin compound with significant applications in various fields due to its unique properties.InChI:InChI=1/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,35,38-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-

What is the HEMATOPORPHYRIN?

HEMATOPORPHYRIN is , while it's Molecular Formula is C34H38 N4 O6. Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

What is the CAS number for HEMATOPORPHYRIN?

The CAS number of HEMATOPORPHYRIN is 14459-29-1.

What is HEMATOPORPHYRIN (14459-29-1) used for?

HEMATOPORPHYRIN, also known as Photodyn or Sensibion, is a dicarboxylic acid that is a derivative of protoporphyrin IX. It is prepared from hemin and has its vinyl groups at positions 7 and 12 replaced by 1-hydroxyethyl groups. HEMATOPORPHYRIN is a porphyrin compound with significant applications in various fields due to its unique properties.InChI:InChI=1/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,35,38-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-

Product classification

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14459-29-1

Product Name:HEMATOPORPHYRIN
Molecular Formula:C34H38 N4 O6
Molecular Weight:598.699

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Product Details

pd_meltingpoint:172.5°C

Purity:99%

Manufacturer supply high quality HEMATOPORPHYRIN 14459-29-1 with GMP standards

Molecular Formula:C34H38 N4 O6
Molecular Weight:598.699
Melting Point:172.5°C
Refractive Index:1.6000 (estimate)
Boiling Point:1192.7°Cat760mmHg
Flash Point:675.1°C
PSA：171.36000
Density:1.32g/cm³
LogP:2.64570

HEMATOPORPHYRIN(Cas 14459-29-1) Usage

Hazard	Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.
Purification Methods	Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]
Definition	ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

InChI:InChI=1/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,35,38-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-

14459-29-1 Relevant articles

Interaction of dicarboxylic metalloporphyrins with liposomes. The effect of pH on membrane binding revisited

Kepczynski, Mariusz,Ehrenberg, Benjamin

, p. 486 - 492 (2002)

The acid-base properties of Zn-hematopor...

Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents

-

, (2008/06/13)

This invention relates to new preparatio...

Antibody-therapeutic agent conjugates

-

, (2008/06/13)

The Chemistry of Pyrrolic Compounds. XLV. Haematoporphyrin Derivative: Haematoporphyrin Diacetate as the Main Product of the Reaction of Haematoporphyrin with a Mixture of Acetic and Sulfuric Acids

Clezy, Peter S.,Hai, Ton That,Henderson, Robert W.,Thuc, Le van

, p. 585 - 597 (2007/10/02)

A mixture of acetic and sulfuric acids c...

14459-29-1 Process route

: 14459-29-1
hematoporphyrin

Conditions

Conditions	Yield
Dihydro-haematoporphyrin durch Disproportionierung;
Dihydro-haematoporphyrin,Jod;
Dihydro-haematoporphyrin,Chloranil;
Dihydro-haematoporphyrin,^3-;
Dihydro-haematoporphyrin,O2;
Dihydro-haematoporphyrin,andere Oxydationsmittel;
Tetrahydro-haematoporphyrin,Jod;
Tetrahydro-haematoporphyrin,Chloranil;
Tetrahydro-haematoporphyrin,^3-;
Tetrahydro-haematoporphyrin,O2;
Tetrahydro-haematoporphyrin,andere Oxydationsmittel;
Hexahydro-haematoporphyrin,Jod;
Hexahydro-haematoporphyrin,Chloranil;
Hexahydro-haematoporphyrin,^3-;
Hexahydro-haematoporphyrin,O2;
Hexahydro-haematoporphyrin,andere Oxydationsmittel;

: 14459-29-1
hematoporphyrin

: 32562-61-1,119366-88-0,119366-89-1,131070-54-7,131070-74-1,6033-09-6
hematoporphyrin-dimethyl ester

Conditions

Conditions	Yield

14459-29-1 Upstream products

5522-66-7
3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester
10591-31-8
diacetyldeuteroporphyrin IX dimethyl ester
32562-61-1
hematoporphyrin-dimethyl ester
75162-60-6
O,O'-diacetyl-hematoporphyrin-dimethyl ester

14459-29-1 Downstream products

600-28-2
2,3-dimethyl-1H-pyrrole
52091-04-0
3-(4,5-dimethyl-pyrrol-3-yl)-propionic acid
487-66-1
2-propionic-3-methylmaleic anhydride
487-65-0
3-(4-methyl-2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-propionic acid

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