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366017-09-6

  • Product Name:Mubritinib
  • Molecular Formula:C25H23F3N4O2
  • Molecular Weight:468.47
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Product Details

pd_meltingpoint:158.0 to 162.0 °C

Purity:99%

Reputable supplier selling Mubritinib 366017-09-6 with stock

  • Molecular Formula:C25H23F3N4O2
  • Molecular Weight:468.47
  • Vapor Pressure:2.43E-15mmHg at 25°C 
  • Melting Point:158.0 to 162.0 °C 
  • Refractive Index:1.577 
  • Boiling Point:620.897 °C at 760 mmHg 
  • PKA:1.45±0.10(Predicted) 
  • Flash Point:329.307 °C 
  • PSA：65.97000 
  • Density:1.258 g/cm3 
  • LogP:6.05720 

Mubritinib(Cas 366017-09-6) Usage

Biological Activity

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

InChI:InChI=1/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+

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