What is the 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE?

2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE is Off-white solid, while it's Molecular Formula is C13H12N4. Off-white solid Carcinogen

What is the CAS number for 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE?

The CAS number of 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE is 105650-23-5.

What is the 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE?

2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE is Off-white solid, while it's Molecular Formula is C13H12N4. Off-white solid Carcinogen

What is the CAS number for 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE?

The CAS number of 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE is 105650-23-5.

Product classification

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105650-23-5

Q: What is 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (105650-23-5) used for?

2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE, also known as a mutagenic heterocyclic amine, is an imidazopyridine derivative with a methyl, amino, and phenyl group substitution at positions 1, 2, and 6, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish, and it is characterized by its off-white solid appearance.InChI:InChI=1/C13H12N4/c1-17-11-7-10(9-5-3-2-4-6-9)8-15-12(11)16-13(17)14/h2-8H,1H3,(H2,14,15,16)

Product Name:2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
Molecular Formula:C₁₃H₁₂N₄
Molecular Weight:224.265
Appearance:Off-white solid

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Product Details

pd_meltingpoint:300 °C

Appearance:Off-white solid

Purity:99%

Top Quality 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE 105650-23-5 Hot Sell In Stock

Molecular Formula:C13H12N4
Molecular Weight:224.265
Appearance/Colour:Off-white solid
Vapor Pressure:5.74E-09mmHg at 25°C
Melting Point:300 °C
Refractive Index:1.699
Boiling Point:468.94 °C at 760 mmHg
PKA:7.72±0.30(Predicted)
Flash Point:237.407 °C
PSA：56.73000
Density:1.3 g/cm³
LogP:2.79870

2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE(Cas 105650-23-5) Usage

Safety Profile	Confirmed carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx,.
Carcinogenicity	PhIP is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting genotoxicity data.
Definition	ChEBI: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in coo ed meat and fish.

InChI:InChI=1/C13H12N4/c1-17-11-7-10(9-5-3-2-4-6-9)8-15-12(11)16-13(17)14/h2-8H,1H3,(H2,14,15,16)

105650-23-5 Relevant articles

Synthesis of a new isomer of creatinine and its use in the preparation of the food mutagen 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PHIP)

Bergman, Jan

, p. 5631 - 5632 (2009)

Base-induced cyclization of N′-cyanometh...

Indole: A Promising Scavenging Agent for Methylglyoxal and Related Carbonyls in Tryptophan Containing Maillard Model Systems

Ghassem Zadeh, Raheleh,Yaylayan, Varoujan

, p. 6359 - 6365 (2019)

In situ generation of efficient carbonyl...

A test of the mutagenicity of cooked meats in vivo

Heddle, John A.,Knize, Mark G.,Dawod, David,Zhang, Xue-Bin

, p. 103 - 107 (2001)

There is a correlation between intestina...

Cross-coupling reaction of 2-halo1-methyl-1H-imidazo[4,5-b]pyridine offers a new synthetic route to mutagenic heterocyclic amine-PHIP and DMIP

Sajith, Ayyiliath M.,Muralidharan, Arayambath,Karuvalam, Ranjith P.,Haridas, Karickal R.

supporting information, p. 361 - 364 (2013/07/26)

A modified synthetic approach to the syn...

Synthesis and mutagenic potency of structural isomers of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Chrisman,Knize,Tanga

experimental part, p. 1641 - 1649 (2009/08/09)

(Chemical Equation Presented) Synthesis ...

105650-23-5 Process route

: 125572-33-0
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

: 105650-23-5
2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With sodium amide; In xylene; at 130 ℃; for 1.5h;	90.2%
With sodium amide;	80%
With 15-crown-5; sodium amide; In xylene; at 130 ℃; for 1.5h;	20 % Turnov.

: 878996-00-0
2-amino-1-methylbenzothieno[3,2-e]imidazo[4,5-b]pyridine

: 105650-23-5
2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With sodium hydroxide; nickel; In 1,4-dioxane; ethanol; Heating;	35%

105650-23-5 Upstream products

506-68-3
bromocyane
152684-14-5
3-methylamino-2-nitro-5-phenylpyridine
107351-81-5
2-amino-3-methylamino-5-phenylpyridine
125572-33-0
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

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