What is the Pheophorbide A?

Pheophorbide A is , while it's Molecular Formula is C35H36N4O5. Pheophorbide-a has been used as a photosensitizer: for the photodynamic therapy (PDT) in oral cancer cell linesto test its effect on inducing oxidative stress and death in L. amazonensisto test its effect on the viability of HeLa cells

What is the CAS number for Pheophorbide A?

The CAS number of Pheophorbide A is 15664-29-6.

What is Pheophorbide A (15664-29-6) used for?

Pheophorbide A is a chlorophyll-related compound that has garnered significant attention for its potential anti-tumor and anti-cancer properties. It is derived from the natural breakdown of chlorophyll, which is the primary pigment in plants responsible for photosynthesis. Pheophorbide A exhibits unique characteristics that make it a promising candidate for various therapeutic applications, particularly in the field of oncology.

What is the Pheophorbide A?

Pheophorbide A is , while it's Molecular Formula is C35H36N4O5. Pheophorbide-a has been used as a photosensitizer: for the photodynamic therapy (PDT) in oral cancer cell linesto test its effect on inducing oxidative stress and death in L. amazonensisto test its effect on the viability of HeLa cells

What is the CAS number for Pheophorbide A?

The CAS number of Pheophorbide A is 15664-29-6.

What is Pheophorbide A (15664-29-6) used for?

Pheophorbide A is a chlorophyll-related compound that has garnered significant attention for its potential anti-tumor and anti-cancer properties. It is derived from the natural breakdown of chlorophyll, which is the primary pigment in plants responsible for photosynthesis. Pheophorbide A exhibits unique characteristics that make it a promising candidate for various therapeutic applications, particularly in the field of oncology.

Product classification

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15664-29-6

Product Name:Pheophorbide A
Molecular Formula:C₃₅H₃₆N₄O₅
Molecular Weight:592.695

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Product Details

pd_meltingpoint:191-195 °C

Purity:99%

Manufacturer supply top purity Pheophorbide A 15664-29-6 with ISO standards

Molecular Formula:C35H36N4O5
Molecular Weight:592.695
Melting Point:191-195 °C
Boiling Point:1018.984 °C at 760 mmHg
Flash Point:570.061 °C
PSA：136.97000
Density:1.282 g/cm³
LogP:3.53890

15664-29-6 Relevant articles

ELECTROPHILIC SUBSTITUTION AT THE δ-METHINE BRIDGE OF PHEOPHORBIDE a AND a'

Hynninen, Paavo H.,Loetjoenen, Simo

, p. 1845 - 1846 (1981)

A chloro-substituted derivative was prep...

Anti-tumor evaluation of a novel methoxyphenyl substituted chlorin photosensitizer for photodynamic therapy

Cao, Lei,Dong, Yi,Li, Guangzhe,Li, Yueqing,Wang, Liu,Zhao, Weijie

, (2020)

Photodynamic therapy (PDT) is a non-inva...

Effect of dietary chlorophyll derivatives on mutagenesis and tumor cell growth

Chernomorsky, Simon,Segelman, Alvin,Poretz, Ronald D.

, p. 313 - 322 (1999)

Much attention in recent years has been ...

Synthesis of potential antitumor agents, dimeric and trimeric chlorins, from methylpheophorbide a

Belykh,Mal'Shakova,Yudina,Zavadskaya,Khudyaev,Kuchin

, p. 719 - 728 (2011)

A series of dimeric and trimeric chlorin...

Design, synthesis and biological evaluation of novel 31-hexyloxy chlorin e6-based 152- or 131-amino acid derivatives as potent photosensitizers for photodynamic therapy

Zhang, Xing-Jie,Han, Gui-Yan,Guo, Chang-Yong,Ma, Zhi-Qiang,Lin, Mei-Yu,Wang, Yuan,Miao, Zhen-Yuan,Zhang, Wan-Nian,Sheng, Chun-Quan,Yao, Jian-Zhong

, (2020)

This study aimed to improve the biologic...

Synthesis and biological evaluation of new water-soluble photoactive chlorin conjugate for targeted delivery

Otvagin, Vasilii F.,Nyuchev, Alexander V.,Kuzmina, Natalia S.,Grishin, Ivan D.,Gavryushin, Andrei E.,Romanenko, Yuliya V.,Koifman, Oscar I.,Belykh, Dmitrii V.,Peskova, Nina N.,Shilyagina, Natalia Yu,Balalaeva, Irina V.,Fedorov, Alexey Yu.

, p. 740 - 750 (2018)

A new water-soluble conjugate, consistin...

Synthesis of chlorins with a distal vinyl group

Mal'Shakova,Belykh,Kuchin

, p. 197 - 200 (2007)

A series of chlorins containing a vinyl ...

Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents

You, Hyun,Yoon, Hyo-Eun,Yoon, Jung-Hoon,Ko, Hyojin,Kim, Yong-Chul

, p. 5383 - 5391 (2011)

Pheophorbide-a, a chlorine based photose...

Distribution of chlorophyll- and bacteriochlorophyll-derived photosensitizers in human blood plasma

Dandler, Joerg,Wilhelm, Brigitte,Scheer, Hugo

, p. 182 - 193 (2010)

Chlorophylla and, in particular, bacteri...

Synthesis of Covalently Linked dimeric Derivatives of Chlorophyll a, Pyrochlorophyll a, Chlorophyll b, and Bacteriochlorophyll a

Wasielewski, Michael R.,Svec, Walter A.

, p. 1969 - 1974 (1980)

Bis(chlorophyllide) ethylene glycol dies...

Amino acid derivatives of pyropheophorbide-a ethers as photosensitizer: Synthesis and photodynamic activity

Meng, Zhi,Shan, Bin,Zhang, Ling,Han, Gui-Yan,Liu, Ming-Hui,Jia, Ning-Yang,Miao, Zhen-Yuan,Zhang, Wan-Nian,Sheng, Chun-Quan,Yao, Jian-Zhong

, p. 623 - 626 (2016)

Ten new water-soluble amino acid conjuga...

Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy

Meng, Zhi,Yu, Bin,Han, Guiyan,Liu, Minghui,Shan, Bin,Dong, Guoqiang,Miao, Zhenyuan,Jia, Ningyang,Tan, Zou,Li, Buhong,Zhang, Wannian,Zhu, Haiying,Sheng, Chunquan,Yao, Jianzhong

, p. 4999 - 5010 (2016)

The development of novel photosensitizer...

Effects of noncovalently bound quinones on the ground and triplet states of zinc chlorins in solution and bound to de novo synthesized peptides

Mennenga, Anke,Gaertner, Wolfgang,Lubitz, Wolfgang,Goerner, Helmut

, p. 5444 - 5453 (2006)

The Qy absorption band of two chlorophyl...

Pheophytinization kinetics of chlorophyll c under weakly acidic conditions: Effects of acrylic acid residue at the 17-position

Sadaoka, Kana,Shoji, Sunao,Hirota, Keiya,Tsukatani, Yusuke,Yoshitomi, Taichi,Tamiaki, Hitoshi,Kashimura, Shigenori,Saga, Yoshitaka

, p. 6915 - 6919 (2013)

Pheophytinization of chlorophyll (Chl) c...

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

Zhang, Xingjie,Meng, Zhi,Ma, Zhiqiang,Liu, Junhong,Han, Guiyan,Ma, Fujia,Jia, Ningyang,Miao, Zhenyuan,Zhang, Wannian,Sheng, Chunquan,Yao, Jianzhong

, p. 247 - 249 (2019)

Eight new water-soluble amino acid conju...

In vitro demethoxycarbonylation of various chlorophyll analogs by a BciC enzyme

Teramura, Misato,Harada, Jiro,Tamiaki, Hitoshi

, p. 163 - 171 (2019)

Unique light-harvesting antennas in the ...

Semi-synthesis and HPLC analysis of (bacterio)chlorophyllides possessing a propionic acid residue at the C17-position

Teramura, Misato,Tamiaki, Hitoshi

, p. 423 - 436 (2018)

Various chlorophyll and bacteriochloroph...

Opening of the extra ring in pheophorbide a methyl ester by the action of amines as a one-step method for introduction of additional fragments at the periphery of chlorin macroring

Belykh,Kopylov,Gruzdev,Kuchin

, p. 577 - 585 (2010)

Opening of the extra ring in pheophorbid...

Novel chlorin e4 derivative, pharmaceutically acceptable salt thereof, and preparation methods and application of novel chlorin e4 derivative and thepharmaceutically acceptable salt thereof

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Page/Page column 14, (2021/10/27)

The invention belongs to the technical f...

15664-29-6 Process route

: 603-17-8
pheophytin a

: 15664-29-6
pheophorbide-a

Conditions

Conditions	Yield
With trifluoroacetic acid; In water; at 0 ℃; for 1h; Inert atmosphere; Darkness;	58%
With hydrogenchloride;
With enzyme-substance from heracleum spondylium;