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RU 58841, is a specific androgen receptor antagonist or anti-androgen, that has shown to have effect on hair growth.
4-Bromobutyl acetate
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
![4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile](/upload/2026/5/128083ba-d29d-4b0c-99cb-0afa89a0df27.png)
4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
| Conditions | Yield |
|---|---|
|
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.25h;
4-Bromobutyl acetate;
In
N,N-dimethyl-formamide; mineral oil;
at 50 ℃;
for 2h;
|
80% |
toluene ethanol
4-Bromobutyl acetate
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
| Conditions | Yield |
|---|---|
|
In
N-methyl-acetamide; methanol; ethanol; dichloromethane; water;
|
The CAS number of RU 58841 is 154992-24-2.
More information of RU 58841 154992-24-2 are:
|
CAS Number |
154992-24-2 |
|
Density |
1.397 g/cm3 |
|
Boiling Point |
493.588 °C at 760 mmHg |
|
Flash Point |
252.313 °C |
|
Vapor Pressure |
1.47E-10mmHg at 25°C |
|
Refractive Index |
1.559 |
|
HS CODE |
2933990090 |
|
PSA |
84.64000 |
|
LogP |
2.89968 |
|
Pka |
15.09±0.10(Predicted) |
Synonyms for RU 58841 154992-24-2:4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-trifluoromethylbenzonitrile;RU 58841;
The chemical formula of RU 58841 is C17H18F3N3O3 which containing 17 Carbon atoms,18 Hydrogen atoms,3 Fluorine atoms,3 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of RU 58841 is 369.343.
RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
InChI:InChI=1/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
Relevant articles related to RU 58841:
|
Article |
Source |
|
Phenylimidazolidine preparation process |
- , (2008/06/13) |
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