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pd_meltingpoint:250-256 °C (dec.)
Appearance:Pale yellow to yellow crystalline powder
Purity:99%
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Hazard |
Moderately toxic by ingestion. |
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Definition |
ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. |
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Brand name |
Camptosar (Pharmacia &Upjohn) . |
InChI:InChI=1/C33H38N4O6.ClH/c1-3-22-23-9-8-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)16-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1
The invention discloses a synthesis meth...
The present invention is directed to a n...
irinotecan hydrochloirde
irinotecan hydrochloride trihydrate
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; water; In ethanol; at 75 - 80 ℃;
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87% |
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With water; In ethanol; Heating / reflux;
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4-piperidinopiperidine-1-carbonyl chloride
7-ethyl-10-hydroxycamptothecin
irinotecan hydrochloride trihydrate
| Conditions | Yield |
|---|---|
|
4-piperidinopiperidine-1-carbonyl chloride; 7-ethyl-10-hydroxycamptothecin; With potassium carbonate; In pyridine; dichloromethane; at 20 ℃; for 6h;
With hydrogenchloride; In pyridine; dichloromethane; water;
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90% |
irinotecan hydrochloirde
4-piperidinopiperidine-1-carbonyl chloride
7-ethyl-10-hydroxycamptothecin
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