ML277 is , while it's Molecular Formula is C23H25N3O4S2. ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

What is the CAS number for ML277?

The CAS number of ML277 is 1401242-74-7.

What is ML277 (1401242-74-7) used for?

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of ML277 at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

ML277 is , while it's Molecular Formula is C23H25N3O4S2. ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

What is the CAS number for ML277?

The CAS number of ML277 is 1401242-74-7.

What is ML277 (1401242-74-7) used for?

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of ML277 at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

Product classification

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1401242-74-7

Product Name:ML277
Molecular Formula:C23H25N3O4S2
Molecular Weight:471.59

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Product Details

Purity:99%

Manufacturer supply good quality ML277 1401242-74-7 with stock

Molecular Formula:C23H25N3O4S2
Molecular Weight:471.59
PKA:8.37±0.70(Predicted)
PSA：128.71000
Density:1.341±0.06 g/cm3(Predicted)
LogP:5.97720

1401242-74-7 Relevant articles

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1- tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K v7.1 (KCNQ1) potassium channel activator

Mattmann, Margrith E.,Yu, Haibo,Lin, Zhihong,Xu, Kaiping,Huang, Xiaofang,Long, Shunyou,Wu, Meng,McManus, Owen B.,Engers, Darren W.,Le, Uyen M.,Li, Min,Lindsley, Craig W.,Hopkins, Corey R.

, p. 5936 - 5941 (2012/11/07)

A high-throughput screen utilizing a dep...

1401242-74-7 Process route

: C₁₆H₁₉N₃O₂S

: 98-59-9
p-toluenesulfonyl chloride

: 1401242-74-7
ML₂₇₇

Conditions

Conditions	Yield
With triethylamine; In dichloromethane; at 20 ℃;

: 28697-17-8
N-BOC-D-pipecolic acid

: 1401242-74-7
ML₂₇₇

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: triethylamine / dichloromethane / 20 °C With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

1401242-74-7 Upstream products

28697-17-8
N-BOC-D-pipecolic acid
2104-04-3
4-(4-methoxyphenyl)-1,3-thiazol-2-amine
1400283-95-5
C₂₁H₂₇N₃O₄S
98-59-9
p-toluenesulfonyl chloride

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