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1428630-86-7

Q: What is the CAS number for 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide?

The CAS number of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide is 1428630-86-7.

Product Name:ML 254
Molecular Weight:310.328

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Product Details

Purity:99%

Factory Export Top Purity ML 254 1428630-86-7 In Stock

Molecular Formula:C₁₈H₁₅FN₂O₂
Molecular Weight:310.328

1428630-86-7 Relevant articles

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): Discovery of 5-((3-fluorophenyl)ethynyl)- N -(3-methyloxetan-3-yl)picolinamide (ML254)

Turlington, Mark,Noetzel, Meredith J.,Chun, Aspen,Zhou, Ya,Gogliotti, Rocco D.,Nguyen, Elizabeth D.,Gregory, Karen J.,Vinson, Paige N.,Rook, Jerri M.,Gogi, Kiran K.,Xiang, Zixiu,Bridges, Thomas M.,Daniels, J. Scott,Jones, Carrie,Niswender, Colleen M.,Meiler, Jens,Jeffrey Conn,Lindsley, Craig W.,Stauffer, Shaun R.

, p. 7976 - 7996 (2013/11/06)

Positive allosteric modulators (PAMs) of...

SUBSTITUED 5-(PROP-1-YN-1-YL)PICOLINAMIDE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

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Paragraph 00511; 00513, (2013/04/13)

In one aspect, the invention relates to ...

1428630-86-7 Process route

: 874473-14-0
3-methyloxetane-3-amine

: 1403771-21-0
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid

: 1428630-86-7
5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide

Conditions

Conditions	Yield
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere; 3-methyloxetane-3-amine; In N,N-dimethyl-formamide; Inert atmosphere;

: 2561-17-3
1-ethynyl-3-fluoro-benzene

: 1428630-86-7
5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 0.75 h / 90 °C / Inert atmosphere 2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere 2.2: Inert atmosphere With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; 1.1: \|Sonogashira Cross-Coupling;

Yield

Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine / N,N-dimethyl-formamide / 0.75 h / 90 °C / Inert atmosphere

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; 1.1: |Sonogashira Cross-Coupling;

1428630-86-7 Upstream products

2561-17-3
1-ethynyl-3-fluoro-benzene
874473-14-0
3-methyloxetane-3-amine
1403771-21-0
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid
30766-11-1
5-bromoisonicotinic acid

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