What is the Lemborexant?

Lemborexant is , while it's Molecular Formula is C22H20F2N4O2. Lemborexant is a novel orexin receptor antagonist and is used in the treatment of insomnia, characterised by difficulties with sleep onset or sleep maintenance. Orexins are neuropeptides involved in regulating sleep and arousal by promoting wakefulness. Lemborexant blocks the binding of orexins A and B to their receptors 1 and 2 thereby reducing wakefulness and promoting sleep. Suvorexant is the other orexin receptor antagonist marketed in Australia for insomnia.

What is the CAS number for Lemborexant?

The CAS number of Lemborexant is 1369764-02-2.

What is Lemborexant (1369764-02-2) used for?

Lemborexant is a newer orexin receptor antagonist which is submitted to US FDA for review as new drug application for the treatment of insomnia after completing two key Phase 3 studies of lemborexant – SUNRISE 1 (Study 304) and SUNRISE 2 (Study 303).

What is the Lemborexant?

Lemborexant is , while it's Molecular Formula is C22H20F2N4O2. Lemborexant is a novel orexin receptor antagonist and is used in the treatment of insomnia, characterised by difficulties with sleep onset or sleep maintenance. Orexins are neuropeptides involved in regulating sleep and arousal by promoting wakefulness. Lemborexant blocks the binding of orexins A and B to their receptors 1 and 2 thereby reducing wakefulness and promoting sleep. Suvorexant is the other orexin receptor antagonist marketed in Australia for insomnia.

What is the CAS number for Lemborexant?

The CAS number of Lemborexant is 1369764-02-2.

What is Lemborexant (1369764-02-2) used for?

Lemborexant is a newer orexin receptor antagonist which is submitted to US FDA for review as new drug application for the treatment of insomnia after completing two key Phase 3 studies of lemborexant – SUNRISE 1 (Study 304) and SUNRISE 2 (Study 303).

Product classification

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1369764-02-2

Product Name:Lemborexant
Molecular Formula:C22H20F2N4O2
Molecular Weight:410.423

Inquiry

Product Details

Purity:99%

Export Top Purity Lemborexant 1369764-02-2 In Stock

Molecular Formula:C22H20F2N4O2
Molecular Weight:410.423
Boiling Point:596.1±50.0 °C(Predicted)
PKA:12.30±0.40(Predicted)
PSA：77.00000
Density:1.347±0.06 g/cm3(Predicted)
LogP:3.81500

1369764-02-2 Relevant articles

METHOD FOR MANUFACTURING CYCLOPROPANE COMPOUND

-

, (2021/11/13)

The present invention provides an indust...

Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist

Yoshida, Yu,Naoe, Yoshimitsu,Terauchi, Taro,Ozaki, Fumihiro,Doko, Takashi,Takemura, Ayumi,Tanaka, Toshiaki,Sorimachi, Keiichi,Beuckmann, Carsten T.,Suzuki, Michiyuki,Ueno, Takashi,Ozaki, Shunsuke,Yonaga, Masahiro

, p. 4648 - 4664 (2015/06/30)

The orexin/hypocretin receptors are a fa...

METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF OREXIN-2 RECEPTOR ANTAGONISTS

-

, (2013/08/28)

The present disclosure provides compound...

Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor

Oi, Norihito,Suzuki, Michiyuki,Terauchi, Taro,Tokunaga, Masaki,Nakatani, Yosuke,Yamamoto, Noboru,Fukumura, Toshimitsu,Zhang, Ming-Rong,Suhara, Tetsuya,Higuchi, Makoto

, p. 6371 - 6385 (2013/09/23)

Orexin receptors (OXRs) in the brain hav...

1369764-02-2 Process route

: 1369769-35-6
(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropanecarboxylic acid

: 21717-96-4
2-amino-5-fluoropyridine

: 1369764-02-2
(1R,2S)-2-[{(2,4-dimethylpyrimidin-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 - 60 ℃;	56.4%
(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropanecarboxylic acid; 2-amino-5-fluoropyridine; With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 - 15 ℃; Inert atmosphere; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 25 ℃; Reagent/catalyst; Solvent;	12.54 g

: 1369769-31-2
C₁₇H₁₆ClFN₂O₂

: 21717-96-4
2-amino-5-fluoropyridine

: 1369764-02-2
(1R,2S)-2-[{(2,4-dimethylpyrimidin-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 10 - 60 ℃; for 2h;

1369764-02-2 Upstream products

1369769-31-2
C₁₇H₁₆ClFN₂O₂
21717-96-4
2-amino-5-fluoropyridine
1369769-35-6
(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropanecarboxylic acid
1450905-00-6
(1S,2R)-1-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

1369764-02-2 Downstream products

1369768-78-4
(1R,2S)-2-(((2-methyl-4-bromomethylpyrimidin-5-yl)oxy)methyl)-N-(5-fluoropyridin-2-yl)-2-(3-fluorophenyl)cyclopropanecarboxamide
1369765-96-7
(1R,2S)-2-(((2-methyl-4-hydroxymethylpyrimidin-5-yl)oxy)-methyl)-N-(5-fluoropyridin-2-yl)-2-(3-fluorophenyl)-cyclopropanecarboxamide
1369766-44-8
(1R,2S)-2-{[(4-fluoromethyl-2-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

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