What is the CAY10683 (SantacruzaMate A)?

CAY10683 (SantacruzaMate A) is , while it's Molecular Formula is C15H22N2O3. Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

What is the CAS number for CAY10683 (SantacruzaMate A)?

The CAS number of CAY10683 (SantacruzaMate A) is 1477949-42-0.

What is CAY10683 (SantacruzaMate A) (1477949-42-0) used for?

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

What is the CAY10683 (SantacruzaMate A)?

CAY10683 (SantacruzaMate A) is , while it's Molecular Formula is C15H22N2O3. Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

What is the CAS number for CAY10683 (SantacruzaMate A)?

The CAS number of CAY10683 (SantacruzaMate A) is 1477949-42-0.

What is CAY10683 (SantacruzaMate A) (1477949-42-0) used for?

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

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1477949-42-0

Product Name:Santacruzamate A
Molecular Formula:C15H22N2O3
Molecular Weight:278.35

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Product Details

Purity:99%

Cost-effective and customizable Santacruzamate A 1477949-42-0 in stock

Molecular Formula:C15H22N2O3
Molecular Weight:278.35
Boiling Point:508.1±43.0 °C(Predicted)
PKA:12.68±0.46(Predicted)
PSA：67.43000
Density:1.087±0.06 g/cm3(Predicted)
LogP:2.65340

1477949-42-0 Relevant articles

Synthesis and biological evaluation of Santacruzamate-A based analogues

Randino, Rosario,Gazzerro, Patrizia,Mazitschek, Ralph,Rodriquez, Manuela

, p. 6486 - 6491 (2017)

Several derivatives of Santacruzamate-A,...

Synthesis and biological evaluation of santacruzamate A and analogs as potential anticancer agents

Liu, Qi,Lu, Wenhua,Ma, Mingzhe,Liao, Jianwei,Ganesan,Hu, Yumin,Wen, Shijun,Huang, Peng

, p. 1109 - 1112 (2015/02/05)

Santacruzamate A, a recently discovered ...

SANTACRUZAMATE A COMPOSITIONS AND ANALOGS AND METHODS OF USE

-

Page/Page column 33, (2014/02/16)

The compositions and methods described h...

Santacruzamate A, a potent and selective histone deacetylase inhibitor from the panamanian marine cyanobacterium cf. symploca sp.

Pavlik, Christopher M.,Wong, Christina Y. B.,Ononye, Sophia,Lopez, Dioxelis D.,Engene, Niclas,McPhail, Kerry L.,Gerwick, William H.,Balunas, Marcy J.

, p. 2026 - 2033 (2014/01/06)

A dark brown tuft-forming cyanobacterium...

1477949-42-0 Process route

: 4143-09-3
4-[(ethoxycarbonyl)amino]butanoic acid

: 64-04-0
phenethylamine

: 1477949-42-0
santacruzamate A

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;	92%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;	92%
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 14.25h; Inert atmosphere;	70%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

1477949-42-0 Upstream products

4143-09-3
4-[(ethoxycarbonyl)amino]butanoic acid
64-04-0
phenethylamine

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