What is the ACT-132577?

ACT-132577 is , while it's Molecular Formula is C16H14Br2N6O4S. N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

What is the CAS number for ACT-132577?

The CAS number of ACT-132577 is 1103522-45-7.

What is ACT-132577 (1103522-45-7) used for?

ACT-132577 is a drug compound that belongs to the family of endothelin receptor antagonists. It is an active metabolite of N-Despropyl-macitentan and is used for the treatment of pulmonary arterial hypertension (PAH). Endothelin receptor antagonists work by blocking the action of endothelin-1, a potent vasoconstrictor, thereby reducing blood vessel constriction and improving blood flow in PAH patients.

What is the ACT-132577?

ACT-132577 is , while it's Molecular Formula is C16H14Br2N6O4S. N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

What is the CAS number for ACT-132577?

The CAS number of ACT-132577 is 1103522-45-7.

What is ACT-132577 (1103522-45-7) used for?

ACT-132577 is a drug compound that belongs to the family of endothelin receptor antagonists. It is an active metabolite of N-Despropyl-macitentan and is used for the treatment of pulmonary arterial hypertension (PAH). Endothelin receptor antagonists work by blocking the action of endothelin-1, a potent vasoconstrictor, thereby reducing blood vessel constriction and improving blood flow in PAH patients.

Product classification

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1103522-45-7

Product Name:ACT-132577 (Aprocitentan)
Molecular Formula:C16H14Br2N6O4S
Molecular Weight:546.199

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Product Details

Purity:99%

Cost-effective and customizable ACT-132577 (Aprocitentan) 1103522-45-7 supplier

Molecular Formula:C16H14Br2N6O4S
Molecular Weight:546.199
Boiling Point:705.0±70.0 °C(Predicted)
PKA:13.56±0.60(Predicted)
PSA：150.59000
Density:1.841±0.06 g/cm3(Predicted)
LogP:4.38590

1103522-45-7 Relevant articles

CRYSTALLINE FORMS OF A 4-PYRIMIDINESULFAMIDE DERIVATIVE APROCITENTAN

-

Paragraph 0231, (2020/01/22)

The present invention concerns novel cry...

COMBINATION OF A 4-PYRIMIDINESULFAMIDE DERIVATIVE WITH AN SGLT-2 INHIBITOR FOR THE TREATMENT OF ENDOTHELIN RELATED DISEASES

-

Page/Page column 38, (2019/06/17)

The present invention concerns the compo...

PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES

-

Page/Page column 45, (2015/09/22)

The invention relates to a process for m...

The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist

Bolli, Martin H.,Boss, Christoph,Binkert, Christoph,Buchmann, Stephan,Bur, Daniel,Hess, Patrick,Iglarz, Marc,Meyer, Solange,Rein, Josiane,Rey, Markus,Treiber, Alexander,Clozel, Martine,Fischli, Walter,Weller, Thomas

, p. 7849 - 7861 (2012/10/29)

Starting from the structure of bosentan ...

1103522-45-7 Process route

: 5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-fluoropyrimidine

: 1103522-45-7
ACT-132577

Conditions

Conditions	Yield
With potassium carbonate; SULFAMIDE; In dimethyl sulfoxide; at 70 ℃; for 3h; Solvent;	84%
With potassium carbonate; SULFAMIDE; In water; dimethyl sulfoxide; at 70 - 75 ℃; for 4h; Time; Temperature;	77%
With potassium carbonate; SULFAMIDE; In dimethyl sulfoxide; at 70 ℃; for 3h; Reagent/catalyst;	65%

: 5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-chloropyrimidine

: 1103522-45-7
ACT-132577

Conditions

Conditions	Yield
5-(4-bromophenyl)-4-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-6-chloropyrimidine; With cesium fluoride; In dimethyl sulfoxide; at 70 ℃; for 2.5h; With potassium carbonate; SULFAMIDE; In dimethyl sulfoxide; for 3h; Reagent/catalyst; Heating;	77%

1103522-45-7 Upstream products

441796-09-4
benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide
41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester
1878-68-8
2-(4-bromophenyl)-acetic acid
146533-41-7
5-(4-bromophenyl)-4,6-dichloropyrimidine

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