TH588 is , while it's Molecular Formula is C13H12Cl2N4. TH 588 acts as a novel potent and selective permeable inhibitor of the nudix hydrolase MTH1 protein. It acts as a good tool to show the non-oncogene addiction concept to anti-cancer treatments.

What is the CAS number for TH588?

The CAS number of TH588 is 1609960-31-7.

What is TH588 (1609960-31-7) used for?

TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1?MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death.? TH588 inhibits MTH1/NUDT1 (IC50?= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells.? Active?in vitro?and?in vivo.? Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3?Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4

TH588 is , while it's Molecular Formula is C13H12Cl2N4. TH 588 acts as a novel potent and selective permeable inhibitor of the nudix hydrolase MTH1 protein. It acts as a good tool to show the non-oncogene addiction concept to anti-cancer treatments.

What is the CAS number for TH588?

The CAS number of TH588 is 1609960-31-7.

What is TH588 (1609960-31-7) used for?

TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1?MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death.? TH588 inhibits MTH1/NUDT1 (IC50?= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells.? Active?in vitro?and?in vivo.? Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3?Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4

Product classification

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1609960-31-7

Product Name:TH588
Molecular Formula:C13H12Cl2N4
Molecular Weight:295.17

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Product Details

Purity:99%

Manufacturer supply good quality TH588 1609960-31-7 with stock

Molecular Formula:C13H12Cl2N4
Molecular Weight:295.17
Boiling Point:545.7±60.0 °C(Predicted)
PKA:5.90±0.10(Predicted)
PSA：63.83000
Density:1.505±0.06 g/cm3(Predicted)
LogP:4.26110

1609960-31-7 Relevant articles

MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS

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Page/Page column 111, (2016/04/04)

A compound of formula (I), or a pharmace...

PYRIMIDINE-2,4-DIAMINE DERIVATIVES FOR TREATMENT OF CANCER

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Page/Page column 97; 113, (2014/06/23)

A compound of formula (I), or a pharmace...

1609960-31-7 Process route

: 1609960-31-7
TH588

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 95 ℃;
With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 95 ℃;

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