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1312201-00-5

  • Product Name:Boronic acid, B-[4-[[4-[(Z)-[3-[(4-fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]-
  • Molecular Formula:C24H19BFNO5S
  • Molecular Weight:463.294
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Product Details

Purity:99%

Factory supply Boronic acid, B-[4-[[4-[(Z)-[3-[(4-fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]- 1312201-00-5 with sufficient stock and high standard

  • Molecular Formula:C24H19BFNO5S
  • Molecular Weight:463.294
  • PSA：112.37000 
  • LogP:3.25890 

1312201-00-5 Relevant articles

Structure-based design of novel boronic acid-based inhibitors of autotaxin

Albers, Harald M. H. G.,Hendrickx, Loes J. D.,Van Tol, Rob J. P.,Hausmann, Jens,Perrakis, Anastassis,Ovaa, Huib

experimental part, p. 4619 - 4626 (2011/09/14)

Autotaxin (ATX) is a secreted phosphodie...

1312201-00-5 Process route

(4-((4-formylphenoxy)methyl)phenyl)boronic acid
1229652-28-1

(4-((4-formylphenoxy)methyl)phenyl)boronic acid

3-(4-fluorobenzyl)-1,3-thiazolane-2,4-dione
137660-67-4

3-(4-fluorobenzyl)-1,3-thiazolane-2,4-dione

[4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid
1312201-00-5

[4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid

Conditions
Conditions Yield
With piperidine; In ethanol; for 22h; Reflux;
81%
4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzaldehyde
1312201-10-7

4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzaldehyde

[4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid
1312201-00-5

[4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methyl]phenyl]boronic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: sodium periodate / tetrahydrofuran; water / 0.5 h
1.2: 4 h
2.1: piperidine / ethanol / 22 h / Reflux
With piperidine; sodium periodate; In tetrahydrofuran; ethanol; water;

1312201-00-5 Upstream products

  • 1229652-28-1
    1229652-28-1

    (4-((4-formylphenoxy)methyl)phenyl)boronic acid

  • 137660-67-4
    137660-67-4

    3-(4-fluorobenzyl)-1,3-thiazolane-2,4-dione

  • 1312201-10-7
    1312201-10-7

    4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzaldehyde

  • 149833-95-4
    149833-95-4

    4-((4-bromobenzyl)oxy)benzaldehyde

1312201-00-5 Downstream products

  • 1312201-38-9
    1312201-38-9

    (4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-yl)methyl)phenoxy)methyl)phenyl)boronic acid

  • 1312201-40-3
    1312201-40-3

    (4-((4-((3-(4-fluorobenzyl)-4-hydroxy-2-oxothiazolidin-5-yl)methyl)phenoxy)methyl)phenyl)boronic acid

  • 1312201-42-5
    1312201-42-5

    (4-((4-((3-(4-Fluorobenzyl)-2-oxo-2,3-dihydrothiazol-5-yl)methyl)phenoxy)methyl)phenyl)boronic acid

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