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75225-51-3

  • Product Name:LOVASTATIN HYDROXY ACID, SODIUM SALT
  • Molecular Formula:C24H38O6•H3N
  • Molecular Weight:422.562
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Product Details

pd_meltingpoint:140 - 143oC

Purity:99%

Factory Sells Best Quality LOVASTATIN HYDROXY ACID, SODIUM SALT 75225-51-3 with GMP standards

  • Molecular Formula:C24H38O6
  • Molecular Weight:422.562
  • Vapor Pressure:5.09E-17mmHg at 25°C 
  • Melting Point:140 - 143oC 
  • Boiling Point:602.3°Cat760mmHg 
  • PKA:4.31±0.10(Predicted) 
  • Flash Point:199.1°C 
  • PSA：106.89000 
  • Density:1.14g/cm3 
  • LogP:2.38090 

LOVASTATIN HYDROXY ACID, SODIUM SALT(Cas 75225-51-3) Usage

Definition

ChEBI: A polyketide obtained by hydrolysis of the pyranone ring of lovastatin.

InChI:InChI=1/C24H38O6/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28)/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

75225-51-3 Relevant articles

Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells

Sokalska, Anna,Hawkins, Amanda B.,Yamaguchi, Toshia,Duleba, Antoni J.

, p. 535 - 541 (2019/01/04)

Purpose: To compare effects of lipid-sol...

The evaluation of statins as potential inhibitors of the LEDGF/p75-HIV-1 integrase interaction

Harrison, Angela T.,Kriel, Frederik H.,Papathanasopoulos, Maria A.,Mosebi, Salerwe,Abrahams, Shaakira,Hewer, Raymond

, p. 290 - 295 (2015/03/04)

Lovastatin was identified through virtua...

DUAL ACTION INHIBITORS AGAINST HISTONE DEACETYLASES AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE

-

Paragraph 0099; 0100; 0101, (2014/08/06)

Disclosed herein are novel compounds of ...

Acyltransferase mediated polyketide release from a fungal megasynthase

Xie, Xinkai,Meehan, Michael J.,Xu, Wei,Dorrestein, Pieter C.,Tang, Yi

supporting information; experimental part, p. 8388 - 8389 (2009/10/24)

(Chemical Equation Presented) LovF is a ...

75225-51-3 Process route

lovastatin
75330-75-5,79952-44-6

lovastatin

lovastatin acid
75225-51-3,137767-34-1,76556-02-0,77285-87-1

lovastatin acid

(4R,6R)-4-hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
151006-15-4,79952-42-4,76343-78-7,81739-25-5

(4R,6R)-4-hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one

(3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid
132748-10-8

(3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid

Conditions
Conditions Yield
lovastatin; With methanol; sodium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; at 50 ℃; for 1h;
With methanol; ammonia; water; lovastatin esterase; at 40 ℃; for 43h; pH=9.5;
With hydrogenchloride; In methanol; water; at 12 ℃; pH=2.5;
lovastatin
75330-75-5,79952-44-6

lovastatin

lovastatin acid
75225-51-3,137767-34-1,76556-02-0,77285-87-1

lovastatin acid

Conditions
Conditions Yield
With sodium hydroxide; at 20 ℃; for 0.5h;
With sodium hydroxide; In water; at 20 ℃; for 0.5h;
With methanol; sodium hydroxide; water; at 35 - 40 ℃; pH=8 - 9; Product distribution / selectivity;
With sodium hydroxide; water; Product distribution / selectivity;
With sodium hydroxide; at 20 ℃; for 0.5h;
With methanol; potassium hydroxide; In water; for 8h; Reflux;
With water; sodium hydroxide; pH=7.5;
With sodium hydroxide; In ethanol; at 50 ℃; for 2h;

75225-51-3 Upstream products

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    lovastatin

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    132748-10-8

    (3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid

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75225-51-3 Downstream products

  • 75330-75-5
    75330-75-5

    lovastatin

  • 151006-15-4
    151006-15-4

    (4R,6R)-4-hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one

  • 132748-10-8
    132748-10-8

    (3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid

  • 1431473-49-2
    1431473-49-2

    (1S,3R,7S,8S,8αR)-8-(2-((2R,4R)-4-((tert-butyldimethylchlorosilane)oxy)-6-oxohexahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8α-hexahydronaphthalene-1-yl(4-nitrophenyl)carbonate

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